Tetrahydrofolate synthase

In enzymology, a tetrahydrofolate synthase (EC number|6.3.2.17) is an enzyme that catalyzes the chemical reaction

:ATP + tetrahydropteroyl- [gamma-Glu] n + L-glutamate $ightleftharpoons$ ADP + phosphate + tetrahydropteroyl- [gamma-Glu] n⁺1

The 3 substrates of this enzyme are ATP, [tetrahydropteroyl- [gamma-Glu] n] , and L-glutamate, whereas its 3 products are ADP, phosphate, and [tetrahydropteroyl- [gamma-Glu] n+1] .

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming). Other names in common use include folylpolyglutamate synthase, folate polyglutamate synthetase, formyltetrahydropteroyldiglutamate synthetase, N10-formyltetrahydropteroyldiglutamate synthetase, folylpoly-gamma-glutamate synthase, folylpolyglutamyl synthetase, folylpoly(gamma-glutamate) synthase, folylpolyglutamate synthetase, folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase, FPGS, tetrahydrofolylpolyglutamate synthase, tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming), tetrahydropteroyl- [gamma-Glu] n:L-glutamate gamma-ligase, and (ADP-forming). This enzyme participates in folate biosynthesis.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FGS, PDB link|1JBV, PDB link|1JBW, PDB link|2GC5, PDB link|2GC6, PDB link|2GCA, and PDB link|2GCB.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|63363-84-8."

Gene Ontology (GO) codes