Thymidylate synthase (FAD)
- Thymidylate synthase (FAD)
In enzymology, a thymidylate synthase (FAD) (EC number|2.1.1.148) is an enzyme that catalyzes the chemical reaction
:5,10-methylenetetrahydrofolate + dUMP + FADH2 dTMP + tetrahydrofolate + FAD
The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, dUMP, and FADH2, whereas its 3 products are dTMP, tetrahydrofolate, and FAD.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase. Other names in common use include Thy1, and ThyX. This enzyme participates in pyrimidine metabolism and one carbon pool by folate.
tructural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2AF6, PDB link|2CFA, and PDB link|2GQ2.
References
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External links
Gene Ontology (GO) codes
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