RNA-3'-phosphate cyclase

In enzymology, a RNA-3'-phosphate cyclase (EC number|6.5.1.4) is an enzyme that catalyzes the chemical reaction

:ATP + RNA 3'-terminal-phosphate $ightleftharpoons$ AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

Thus, the two substrates of this enzyme are ATP and RNA 3'-terminal-phosphate, whereas its 3 products are AMP, diphosphate, and RNA terminal-2',3'-cyclic-phosphate.

This enzyme belongs to the family of ligases, specifically those forming phosphoric-ester bonds. The systematic name of this enzyme class is RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming). This enzyme is also called RNA cyclase.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1QMH and PDB link|1QMI.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|85638-41-1."

Gene Ontology (GO) codes