- N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
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N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase Identifiers EC number 6.3.2.26 CAS number 57219-73-5 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase (EC 6.3.2.26) is an enzyme that catalyzes the chemical reaction
- 3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O
3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
The 5 substrates of this enzyme are ATP, L-2-aminohexanedioate, L-cysteine, L-valine, and H2O, whereas its 3 products are AMP, diphosphate, and [[N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine]].
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting). Other names in common use include L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase, ACV synthetase, and L-alpha-aminoadipyl-cysteinyl-valine synthetase. This enzyme participates in penicillin and cephalosporin biosynthesis.
References
- Byford MF, Baldwin JE, Shiau CY, Schofield CJ (1997). "The Mechanism of ACV Synthetase". Chem. Rev. 97 (7): 2631–2650. doi:10.1021/cr960018l. PMID 11851475.
- Theilgaard HB, Kristiansen KN, Henriksen CM, Nielsen J (Pt 1). "Purification and characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Penicillium chrysogenum". Biochem. J. 327: 185–91. PMC 1218779. PMID 9355751. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218779.
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