Glutamate-cysteine ligase

In enzymology, a glutamate-cysteine ligase (EC number|6.3.2.2) is an enzyme that catalyzes the chemical reaction

:ATP + L-glutamate + L-cysteine $ightleftharpoons$ ADP + phosphate + gamma-L-glutamyl-L-cysteine

The 3 substrates of this enzyme are ATP, L-glutamate, and L-cysteine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-glutamate:L-cysteine gamma-ligase (ADP-forming). Other names in common use include gamma-glutamylcysteine synthetase, gamma-glutamyl-L-cysteine synthetase, and gamma-glutamylcysteinyl synthetase. This enzyme participates in glutamate metabolism and glutathione metabolism. At least one compound, [S-Butyl-DL-homocysteine- [S,R] -sulfoximine] is known to inhibit this enzyme.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1V4G, PDB link|1VA6, PDB link|2D32, PDB link|2D33, PDB link|2GWC, and PDB link|2GWD.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-64-7."

Gene Ontology (GO) codes