GCLM

Glutamate-cysteine ligase, modifier subunit, also known as GCLM, is a human gene.cite web | title = Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2730| accessdate = ]

PBB_Summary
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summary_text = Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.cite web | title = Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2730| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dickinson DA, Levonen AL, Moellering DR, "et al." |title=Human glutamate cysteine ligase gene regulation through the electrophile response element. |journal=Free Radic. Biol. Med. |volume=37 |issue= 8 |pages= 1152–9 |year= 2005 |pmid= 15451055 |doi= 10.1016/j.freeradbiomed.2004.06.011
*cite journal | author=Gipp JJ, Bailey HH, Mulcahy RT |title=Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues. |journal=Biochem. Biophys. Res. Commun. |volume=206 |issue= 2 |pages= 584–9 |year= 1995 |pmid= 7826375 |doi=
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457
*cite journal | author=Tsuchiya K, Mulcahy RT, Reid LL, "et al." |title=Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. |journal=Genomics |volume=30 |issue= 3 |pages= 630–2 |year= 1997 |pmid= 8825659 |doi= 10.1006/geno.1995.1293
*cite journal | author=Sierra-Rivera E, Dasouki M, Summar ML, "et al." |title=Assignment of the human gene (GLCLR) that encodes the regulatory subunit of gamma-glutamylcysteine synthetase to chromosome 1p21. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 252–4 |year= 1997 |pmid= 8978789 |doi=
*cite journal | author=Misra I, Griffith OW |title=Expression and purification of human gamma-glutamylcysteine synthetase. |journal=Protein Expr. Purif. |volume=13 |issue= 2 |pages= 268–76 |year= 1998 |pmid= 9675072 |doi= 10.1006/prep.1998.0897
*cite journal | author=Rozet JM, Gerber S, Perrault I, "et al." |title=Structure and refinement of the physical mapping of the gamma- glutamylcysteine ligase regulatory subunit (GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant mesothelioma. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 1-2 |pages= 91–4 |year= 1998 |pmid= 9841137 |doi=
*cite journal | author=Tu Z, Anders MW |title=Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis. |journal=Biochem. J. |volume=336 ( Pt 3) |issue= |pages= 675–80 |year= 1999 |pmid= 9841880 |doi=
*cite journal | author=Tipnis SR, Blake DG, Shepherd AG, McLellan LI |title=Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistance. |journal=Biochem. J. |volume=337 ( Pt 3) |issue= |pages= 559–66 |year= 1999 |pmid= 9895302 |doi=
*cite journal | author=Galloway DC, Blake DG, McLellan LI |title=Regulation of gamma-glutamylcysteine synthetase regulatory subunit (GLCLR) gene expression: identification of the major transcriptional start site in HT29 cells. |journal=Biochim. Biophys. Acta |volume=1446 |issue= 1-2 |pages= 47–56 |year= 1999 |pmid= 10395918 |doi=
*cite journal | author=Levonen AL, Lapatto R, Saksela M, Raivio KO |title=Expression of gamma-glutamylcysteine synthetase during development. |journal=Pediatr. Res. |volume=47 |issue= 2 |pages= 266–70 |year= 2000 |pmid= 10674357 |doi=
*cite journal | author=Nakamura S, Kugiyama K, Sugiyama S, "et al." |title=Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction. |journal=Circulation |volume=105 |issue= 25 |pages= 2968–73 |year= 2002 |pmid= 12081989 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nakamura S, Sugiyama S, Fujioka D, "et al." |title=Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impairment of nitric oxide-mediated coronary vasomotor function. |journal=Circulation |volume=108 |issue= 12 |pages= 1425–7 |year= 2003 |pmid= 12975258 |doi= 10.1161/01.CIR.0000091255.63645.98
*cite journal | author=Inoue Y, Tomisawa M, Yamazaki H, "et al." |title=The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer. |journal=Int. J. Oncol. |volume=23 |issue= 5 |pages= 1333–9 |year= 2004 |pmid= 14532974 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Song IS, Tatebe S, Dai W, Kuo MT |title=Delayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28230–40 |year= 2005 |pmid= 15946948 |doi= 10.1074/jbc.M413103200
*cite journal | author=Chen Y, Shertzer HG, Schneider SN, "et al." |title=Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels. |journal=J. Biol. Chem. |volume=280 |issue= 40 |pages= 33766–74 |year= 2005 |pmid= 16081425 |doi= 10.1074/jbc.M504604200
*cite journal | author=Diaz-Hernandez JI, Almeida A, Delgado-Esteban M, "et al." |title=Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 38992–9001 |year= 2006 |pmid= 16183645 |doi= 10.1074/jbc.M507065200

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