4-chlorobenzoate-CoA ligase

In enzymology, a 4-chlorobenzoate-CoA ligase (EC number|6.2.1.33) is an enzyme that catalyzes the chemical reaction

:4-chlorobenzoate + CoA + ATP $ightleftharpoons$ 4-chlorobenzoyl-CoA + AMP + diphosphate

The 3 substrates of this enzyme are 4-chlorobenzoate, CoA, and ATP, whereas its 3 products are 4-chlorobenzoyl-CoA, AMP, and diphosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 4-chlorobenzoate:CoA ligase. This enzyme participates in 2,4-dichlorobenzoate degradation. It employs one cofactor, magnesium.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1T5D and PDB link|1T5H.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|141583-20-2."

Gene Ontology (GO) codes