3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase

In enzymology, a 3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase (EC number|6.2.1.28) is an enzyme that catalyzes the chemical reaction

:ATP + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + CoA $ightleftharpoons$ AMP + diphosphate + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA

The 3 substrates of this enzyme are ATP, (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate, and CoA, whereas its 3 products are AMP, diphosphate, and (25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate:CoA ligase (AMP-forming). Other names in common use include 3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase, DHCA-CoA ligase, and 3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming). This enzyme participates in bile acid biosynthesis.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|118732-03-9."

Gene Ontology (GO) codes