- Naphthoate synthase
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naphthoate synthase Identifiers EC number 4.1.3.36 CAS number 72506-71-9 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a naphthoate synthase (EC 4.1.3.36) is an enzyme that catalyzes the chemical reaction
- o-succinylbenzoyl-CoA
CoA + 1,4-dihydroxy-2-naphthoate
Hence, this enzyme has one substrate, o-succinylbenzoyl-CoA, and two products, CoA and 1,4-dihydroxy-2-naphthoate.
This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing CoA-forming). Other names in common use include 1,4-dihydroxy-2-naphthoate synthase, dihydroxynaphthoate synthase, and o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing). This enzyme participates in ubiquinone biosynthesis.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1Q51, 1Q52, 1RJM, 1RJN, and 2IEX.
References
- Kolkmann R, Leistner E (1987). "4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis". Z. Naturforsch. [C]. 42 (11–12): 1207–14. PMID 2966501.
- Meganathan R, Bentley R (1979). "Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes". J. Bacteriol. 140 (1): 92–8. PMC 216783. PMID 500558. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=216783.
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