(S)-2-haloacid dehalogenase

In enzymology, a (S)-2-haloacid dehalogenase (EC number|3.8.1.2) is an enzyme that catalyzes the chemical reaction

:(S)-2-haloacid + H₂O $ightleftharpoons$ (R)-2-hydroxyacid + halide

Thus, the two substrates of this enzyme are (S)-2-haloacid and H₂O, whereas its two products are (R)-2-hydroxyacid and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is (S)-2-haloacid halidohydrolase. Other names in common use include 2-haloacid dehalogenase [ambiguous] , 2-haloacid halidohydrolase [ambiguous] [ambiguous] , 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, 2-halocarboxylic acid dehalogenase II, DL-2-haloacid dehalogenase [ambiguous] , L-2-haloacid dehalogenase, and L-DEX. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,2-dichloroethane degradation.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AQ6, PDB link|1JUD, PDB link|1QH9, PDB link|1QQ5, PDB link|1QQ6, PDB link|1QQ7, PDB link|1ZRM, PDB link|1ZRN, PDB link|2NO4, and PDB link|2NO5.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37289-39-7."

Gene Ontology (GO) codes