Estrone sulfotransferase

In enzymology, an estrone sulfotransferase (EC number|2.8.2.4) is an enzyme that catalyzes the chemical reaction

:3'-phosphoadenylyl sulfate + estrone $ightleftharpoons$ adenosine 3',5'-bisphosphate + estrone 3-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and estrone, whereas its two products are adenosine 3',5'-bisphosphate and estrone 3-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase. Other names in common use include 3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase, estrogen sulfotransferase, estrogen sulphotransferase, oestrogen sulphotransferase, and 3'-phosphoadenylylsulfate:oestrone sulfotransferase. This enzyme participates in androgen and estrogen metabolism and sulfur metabolism.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AQU, PDB link|1AQY, PDB link|1BO6, PDB link|1G3M, and PDB link|1HY3.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9026-06-6."

Gene Ontology (GO) codes