Biotin synthase

In enzymology, a biotin synthase (EC number|2.8.1.6) is an enzyme that catalyzes the chemical reaction

:dethiobiotin + sulfur + 2 S-adenosyl-L-methionine $ightleftharpoons$ biotin + 2 L-methionine + 2 5'-deoxyadenosine

The 3 substrates of this enzyme are dethiobiotin, sulfur, and S-adenosyl-L-methionine, whereas its 3 products are biotin, L-methionine, and 5'-deoxyadenosine.

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is dethiobiotin:sulfur sulfurtransferase. This enzyme participates in biotin metabolism. It employs one cofactor, iron-sulfur.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1R30.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|80146-93-6."

Gene Ontology (GO) codes