8-amino-7-oxononanoate synthase

In enzymology, a 8-amino-7-oxononanoate synthase (EC number|2.3.1.47) is an enzyme that catalyzes the chemical reaction

:6-carboxyhexanoyl-CoA + L-alanine $ightleftharpoons$ 8-amino-7-oxononanoate + CoA + CO₂

Thus, the two substrates of this enzyme are 6-carboxyhexanoyl-CoA and L-alanine, whereas its 3 products are 8-amino-7-oxononanoate, CoA, and CO₂.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating). Other names in common use include 7-keto-8-aminopelargonic acid synthetase, 7-keto-8-aminopelargonic synthetase, and 8-amino-7-oxopelargonate synthase. This enzyme participates in biotin metabolism. It employs one cofactor, pyridoxal phosphate.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BS0, PDB link|1DJ9, PDB link|1DJE, and PDB link|2G6W.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9075-61-0."

Gene Ontology (GO) codes