Methionyl-tRNA formyltransferase

Methionyl-tRNA formyltransferase
methionyl-tRNA formyltransferase
Identifiers
EC number 2.1.2.9
CAS number 9015-76-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a methionyl-tRNA formyltransferase (EC 2.1.2.9) is an enzyme that catalyzes the chemical reaction

10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O \rightleftharpoons tetrahydrofolate + N-formylmethionyl-tRNAfMet

The 3 substrates of this enzyme are 10-formyltetrahydrofolate, L-methionyl-tRNAfMet, and H2O, whereas its two products are tetrahydrofolate and N-formylmethionyl-tRNAfMet.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase. Other names in common use include N10-formyltetrahydrofolic-methionyl-transfer ribonucleic, transformylase, formylmethionyl-transfer ribonucleic synthetase, methionyl ribonucleic formyltransferase, methionyl-tRNA Met formyltransferase, methionyl-tRNA transformylase, methionyl-transfer RNA transformylase, methionyl-transfer ribonucleate methyltransferase, and methionyl-transfer ribonucleic transformylase. This enzyme participates in 3 metabolic pathways: methionine metabolism, one carbon pool by folate, and aminoacyl-tRNA biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1FMT and 2FMT.

References

  • Dickerman HW, Steers E Jr, Redfield BG, Weissbach H (1967). "Methionyl soluble ribonucleic acid transformylase. I. Purification and partial characterization". J. Biol. Chem. 242 (7): 1522–5. PMID 5337045. 
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