Strictosidine synthase

In enzymology, a strictosidine synthase (EC number|4.3.3.2) is an enzyme that catalyzes the chemical reaction

:3-alpha(S)-strictosidine + H₂O $ightleftharpoons$ tryptamine + secologanin

Thus, the two substrates of this enzyme are 3-alpha(S)-strictosidine and H₂O, whereas its two products are tryptamine and secologanin.

This enzyme belongs to the family of lyases, specifically amine lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is 3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming). Other names in common use include strictosidine synthetase, STR, and 3-alpha(S)-strictosidine tryptamine-lyase. This enzyme participates in terpenoid biosynthesis and indole and ipecac alkaloid biosynthesis.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2FP8, PDB link|2FP9, PDB link|2FPB, and PDB link|2FPC.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|69669-72-3."

Gene Ontology (GO) codes