S-ribosylhomocysteine lyase

In enzymology, a S-ribosylhomocysteine lyase (EC number|4.4.1.21) is an enzyme that catalyzes the chemical reaction

:S-(5-deoxy-D-ribos-5-yl)-L-homocysteine $ightleftharpoons$ L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione

Hence, this enzyme has one substrate, S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, and two products, L-homocysteine and (4S)-4,5-dihydroxypentan-2,3-dione.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming] . Other names in common use include S-ribosylhomocysteinase, and LuxS. This enzyme participates in methionine metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1JQW, PDB link|2FQO, and PDB link|2FQT.

References

*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|37288-63-4."

Gene Ontology (GO) codes