Dodecenoyl-CoA isomerase

Dodecenoyl-CoA isomerase
dodecenoyl-CoA delta-isomerase
Identifiers
EC number 5.3.3.8
CAS number 62213-29-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dodecenoyl-CoA isomerase (EC 5.3.3.8) is an enzyme that catalyzes the chemical reaction

(3Z)-dodec-3-enoyl-CoA \rightleftharpoons (2E)-dodec-2-enoyl-CoA

Hence, this enzyme has one substrate, (3Z)-dodec-3-enoyl-CoA, and one product, (2E)-dodec-2-enoyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is dodecenoyl-CoA (3Z)-(2E)-isomerase. Other names in common use include dodecenoyl-CoA Delta-isomerase, Delta3-cis-Delta2-trans-enoyl-CoA isomerase, acetylene-allene isomerase, dodecenoyl-CoA Delta-isomerase, and dodecenoyl-CoA Delta3-cis-Delta2-trans-isomerase. This enzyme participates in fatty acid metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1HNO, 1HNU, 1K39, 1PJH, 1SG4, 1WDK, 1WDL, 1WDM, 1XX4, 2CQU, 2D3T, and 2F6Q.

References

  • Miesowicz FM, Bloch K (1979). "Purification of hog liver isomerase. Mechanism of isomerization of 3-alkenyl and 3-alkynyl thioesters". J. Biol. Chem. 254 (13): 5868–77. PMID 376522. 
  • Stoffel W, Ditzer R, Caesar H (1964). "[The metabolism of unsaturated fatty acid. 3. On the beta-oxidation of mono- and polyene-fatty acids. The mechanism of the enzymatic reaction on delta-3-cis-enoyl-CoA compounds]". Hoppe. Seylers. Z. Physiol. Chem. 339 (1): 167–81. PMID 5830064. 
  • Stoffel W and Ecker W (1979). "Delta3-cis,-Delta2-trans-Enoyl-CoA isomerase from rat liver mitochondria". Methods Enzymol. 14: 99–105. doi:10.1016/S0076-6879(69)14019-7. 
  • Stoffel W, Grol M (1978). "Purification and properties of 3-cis-2-trans-enoyl-CoA isomerase (dodecenoyl-CoA delta-isomerase) from rat liver mitochondria". Hoppe. Seylers. Z. Physiol. Chem. 359 (12): 1777–82. doi:10.1515/bchm2.1978.359.2.1777. PMID 738702. 
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