Dodecenoyl-CoA isomerase

dodecenoyl-CoA delta-isomerase
Identifiers
EC number	5.3.3.8
CAS number	62213-29-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a dodecenoyl-CoA isomerase (EC 5.3.3.8) is an enzyme that catalyzes the chemical reaction

(3Z)-dodec-3-enoyl-CoA $\rightleftharpoons$ (2E)-dodec-2-enoyl-CoA

Hence, this enzyme has one substrate, (3Z)-dodec-3-enoyl-CoA, and one product, (2E)-dodec-2-enoyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is dodecenoyl-CoA (3Z)-(2E)-isomerase. Other names in common use include dodecenoyl-CoA Delta-isomerase, Delta3-cis-Delta2-trans-enoyl-CoA isomerase, acetylene-allene isomerase, dodecenoyl-CoA Delta-isomerase, and dodecenoyl-CoA Delta3-cis-Delta2-trans-isomerase. This enzyme participates in fatty acid metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1HNO, 1HNU, 1K39, 1PJH, 1SG4, 1WDK, 1WDL, 1WDM, 1XX4, 2CQU, 2D3T, and 2F6Q.

References

• Miesowicz FM, Bloch K (1979). "Purification of hog liver isomerase. Mechanism of isomerization of 3-alkenyl and 3-alkynyl thioesters". J. Biol. Chem. 254 (13): 5868–77. PMID 376522. 
• Stoffel W, Ditzer R, Caesar H (1964). "[The metabolism of unsaturated fatty acid. 3. On the beta-oxidation of mono- and polyene-fatty acids. The mechanism of the enzymatic reaction on delta-3-cis-enoyl-CoA compounds]". Hoppe. Seylers. Z. Physiol. Chem. 339 (1): 167–81. PMID 5830064. 
• Stoffel W and Ecker W (1979). "Delta3-cis,-Delta2-trans-Enoyl-CoA isomerase from rat liver mitochondria". Methods Enzymol. 14: 99–105. doi:10.1016/S0076-6879(69)14019-7. 
• Stoffel W, Grol M (1978). "Purification and properties of 3-cis-2-trans-enoyl-CoA isomerase (dodecenoyl-CoA delta-isomerase) from rat liver mitochondria". Hoppe. Seylers. Z. Physiol. Chem. 359 (12): 1777–82. doi:10.1515/bchm2.1978.359.2.1777. PMID 738702. 

This isomerase article is a stub. You can help Wikipedia by expanding it.v · Categories: Isomerase stubs EC 5.3.3 Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Anthony L Piscitelli Karel Kesselaers Look at other dictionaries: dodecenoyl-CoA Δ-isomerase — do·de·ce·no·yl CoA Δ isom·er·ase (do″də sə noґəl ko aґ i somґər ās) [EC 5.3.3.8] an enzyme of the isomerase class that catalyzes the shift of a cis double bond at C 2 of an unsaturated fatty acyl CoA to one… …   Medical dictionary Enoyl CoA isomerase — dodecenoyl Coenzyme A delta isomerase (3,2 trans enoyl Coenzyme A isomerase) Identifiers Symbol DCI HUGO 2703 RefSeq …   Wikipedia enoyl CoA isomerase — enoyl CoA isom·er·ase (eґno əl ko aґ i somґə rās) dodecenoyl CoA Δ isomerase …   Medical dictionary List of EC numbers (EC 5) — This list contains a list of EC numbers for the fifth group, EC 5, isomerases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. =EC 5.1: Epimerases and… …   Wikipedia Crotonase family — Enoyl CoA hydratase/isomerase family Identifiers Symbol ECH Pfam PF00378 InterPro …   Wikipedia PECI (gene) — Enoyl CoA delta isomerase 2 PDB rendering based on 2cqu …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”