Corticosteroid side-chain-isomerase

Corticosteroid side-chain-isomerase
corticosteroid side-chain-isomerase
Identifiers
EC number 5.3.1.21
CAS number 75139-73-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a corticosteroid side-chain-isomerase (EC 5.3.1.21) is an enzyme that catalyzes the chemical reaction

11-deoxycorticosterone \rightleftharpoons 20-hydroxy-3-oxopregn-4-en-21-al

Hence, this enzyme has one substrate, 11-deoxycorticosterone, and one product, 20-hydroxy-3-oxopregn-4-en-21-al.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is 11-deoxycorticosterone aldose-ketose-isomerase.

References

  • Martin KO, Oh SW, Lee HJ, Monder C (1977). "Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme". Biochemistry. 16 (17): 3803–9. doi:10.1021/bi00636a013. PMID 901753. 
  • Monder C, Martin KO, Bogumil J (1980). "Presence of epimerase activity in hamster liver corticosteroid side chain isomerase". J. Biol. Chem. 255 (15): 7192–8. PMID 7391077. 
This isomerase article is a stub. You can help Wikipedia by expanding it.