Transformation/transcription domain-associated protein

Transformation/transcription domain-associated protein

Transformation/transcription domain-associated protein, also known as TRRAP, is a human gene.

This is an adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Plays a central role in MYC (c-Myc) transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes.

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Further reading

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citations =
*cite journal | author=Herceg Z, Wang ZQ |title=Rendez-vous at mitosis: TRRAPed in the chromatin. |journal=Cell Cycle |volume=4 |issue= 3 |pages= 383–7 |year= 2006 |pmid= 15711126 |doi=
*cite journal | author=Murr R, Vaissière T, Sawan C, "et al." |title=Orchestration of chromatin-based processes: mind the TRRAP. |journal=Oncogene |volume=26 |issue= 37 |pages= 5358–72 |year= 2007 |pmid= 17694078 |doi= 10.1038/sj.onc.1210605
*cite journal | author=McMahon SB, Van Buskirk HA, Dugan KA, "et al." |title=The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. |journal=Cell |volume=94 |issue= 3 |pages= 363–74 |year= 1998 |pmid= 9708738 |doi=
*cite journal | author=Vassilev A, Yamauchi J, Kotani T, "et al." |title=The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. |journal=Mol. Cell |volume=2 |issue= 6 |pages= 869–75 |year= 1999 |pmid= 9885574 |doi=
*cite journal | author=Brand M, Yamamoto K, Staub A, Tora L |title=Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18285–9 |year= 1999 |pmid= 10373431 |doi=
*cite journal | author=McMahon SB, Wood MA, Cole MD |title=The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. |journal=Mol. Cell. Biol. |volume=20 |issue= 2 |pages= 556–62 |year= 2000 |pmid= 10611234 |doi=
*cite journal | author=Ikura T, Ogryzko VV, Grigoriev M, "et al." |title=Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. |journal=Cell |volume=102 |issue= 4 |pages= 463–73 |year= 2000 |pmid= 10966108 |doi=
*cite journal | author=Brand M, Moggs JG, Oulad-Abdelghani M, "et al." |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187–96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187
*cite journal | author=Lee YJ, Chung TS, Soo Yoon Y, "et al." |title=The role of functional MR imaging in patients with ischemia in the visual cortex. |journal=AJNR. American journal of neuroradiology |volume=22 |issue= 6 |pages= 1043–9 |year= 2001 |pmid= 11415895 |doi=
*cite journal | author=Lang SE, McMahon SB, Cole MD, Hearing P |title=E2F transcriptional activation requires TRRAP and GCN5 cofactors. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32627–34 |year= 2001 |pmid= 11418595 |doi= 10.1074/jbc.M102067200
*cite journal | author=Park J, Kunjibettu S, McMahon SB, Cole MD |title=The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. |journal=Genes Dev. |volume=15 |issue= 13 |pages= 1619–24 |year= 2001 |pmid= 11445536 |doi= 10.1101/gad.900101
*cite journal | author=Fuchs M, Gerber J, Drapkin R, "et al." |title=The p400 complex is an essential E1A transformation target. |journal=Cell |volume=106 |issue= 3 |pages= 297–307 |year= 2001 |pmid= 11509179 |doi=
*cite journal | author=Martinez E, Palhan VB, Tjernberg A, "et al." |title=Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6782–95 |year= 2001 |pmid= 11564863 |doi= 10.1128/MCB.21.20.6782-6795.2001
*cite journal | author=Park J, Wood MA, Cole MD |title=BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. |journal=Mol. Cell. Biol. |volume=22 |issue= 5 |pages= 1307–16 |year= 2002 |pmid= 11839798 |doi=
*cite journal | author=Yanagisawa J, Kitagawa H, Yanagida M, "et al." |title=Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. |journal=Mol. Cell |volume=9 |issue= 3 |pages= 553–62 |year= 2002 |pmid= 11931763 |doi=
*cite journal | author=Nikiforov MA, Chandriani S, Park J, "et al." |title=TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. |journal=Mol. Cell. Biol. |volume=22 |issue= 14 |pages= 5054–63 |year= 2002 |pmid= 12077335 |doi=
*cite journal | author=Ard PG, Chatterjee C, Kunjibettu S, "et al." |title=Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5650–61 |year= 2002 |pmid= 12138177 |doi=
*cite journal | author=Cavusoglu N, Brand M, Tora L, Van Dorsselaer A |title=Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. |journal=Proteomics |volume=3 |issue= 2 |pages= 217–23 |year= 2003 |pmid= 12601814 |doi= 10.1002/pmic.200390030
*cite journal | author=Liu X, Tesfai J, Evrard YA, "et al." |title=c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 20405–12 |year= 2003 |pmid= 12660246 |doi= 10.1074/jbc.M211795200
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423

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