PPP2R5A

Protein phosphatase 2, regulatory subunit B', alpha isoform, also known as PPP2R5A, is a human gene.

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily.cite web | title = Entrez Gene: PPP2R5A protein phosphatase 2, regulatory subunit B', alpha isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5525| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43–51 |year= 2005 |pmid= 15638722 |doi=
*cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11
*cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279
*cite journal | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi=
*cite journal | author=McCright B, Virshup DM |title=Identification of a new family of protein phosphatase 2A regulatory subunits. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26123–8 |year= 1995 |pmid= 7592815 |doi=
*cite journal | author=Zolnierowicz S, Van Hoof C, Andjelković N, "et al." |title=The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. |journal=Biochem. J. |volume=317 ( Pt 1) |issue= |pages= 187–94 |year= 1996 |pmid= 8694763 |doi=
*cite journal | author=Fuhrer DK, Yang YC |title=Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11. |journal=Biochem. Biophys. Res. Commun. |volume=224 |issue= 2 |pages= 289–96 |year= 1996 |pmid= 8702385 |doi=
*cite journal | author=McCright B, Rivers AM, Audlin S, Virshup DM |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22081–9 |year= 1996 |pmid= 8703017 |doi=
*cite journal | author=McCright B, Brothman AR, Virshup DM |title=Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12. |journal=Genomics |volume=36 |issue= 1 |pages= 168–70 |year= 1997 |pmid= 8812429 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, "et al." |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=
*cite journal | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873
*cite journal | author=Ruediger R, Fields K, Walter G |title=Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens. |journal=J. Virol. |volume=73 |issue= 1 |pages= 839–42 |year= 1999 |pmid= 9847399 |doi=
*cite journal | author=Seeling JM, Miller JR, Gil R, "et al." |title=Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. |journal=Science |volume=283 |issue= 5410 |pages= 2089–91 |year= 1999 |pmid= 10092233 |doi=
*cite journal | author=Xu Z, Williams BR |title=The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR. |journal=Mol. Cell. Biol. |volume=20 |issue= 14 |pages= 5285–99 |year= 2000 |pmid= 10866685 |doi=
*cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956–67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956
*cite journal | author=Fleming I, Fisslthaler B, Dimmeler S, "et al." |title=Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. |journal=Circ. Res. |volume=88 |issue= 11 |pages= E68–75 |year= 2001 |pmid= 11397791 |doi=
*cite journal | author=Elder RT, Yu M, Chen M, "et al." |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007
*cite journal | author=Galea MA, Eleftheriou A, Henderson BR |title=ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 45833–9 |year= 2002 |pmid= 11585828 |doi= 10.1074/jbc.M107149200
*cite journal | author=Li X, Virshup DM |title=Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 546–52 |year= 2002 |pmid= 11856313 |doi=

PBB_Controls
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