PPP2R5C

Protein phosphatase 2, regulatory subunit B', gamma isoform, also known as PPP2R5C, is a human gene.cite web | title = Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5527| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5527| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11
*cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279
*cite journal | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi=
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=
*cite journal | author=Nomura N, Nagase T, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=
*cite journal | author=McCright B, Virshup DM |title=Identification of a new family of protein phosphatase 2A regulatory subunits. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26123–8 |year= 1995 |pmid= 7592815 |doi=
*cite journal | author=Akiyama N, Shima H, Hatano Y, "et al." |title=cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase. |journal=Eur. J. Biochem. |volume=230 |issue= 2 |pages= 766–72 |year= 1995 |pmid= 7607250 |doi=
*cite journal | author=Tehrani MA, Mumby MC, Kamibayashi C |title=Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5164–70 |year= 1996 |pmid= 8617797 |doi=
*cite journal | author=Zolnierowicz S, Van Hoof C, Andjelković N, "et al." |title=The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. |journal=Biochem. J. |volume=317 ( Pt 1) |issue= |pages= 187–94 |year= 1996 |pmid= 8694763 |doi=
*cite journal | author=McCright B, Rivers AM, Audlin S, Virshup DM |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22081–9 |year= 1996 |pmid= 8703017 |doi=
*cite journal | author=McCright B, Brothman AR, Virshup DM |title=Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12. |journal=Genomics |volume=36 |issue= 1 |pages= 168–70 |year= 1997 |pmid= 8812429 |doi=
*cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, "et al." |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=
*cite journal | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873
*cite journal | author=Scanlan MJ, Gordan JD, Williamson B, "et al." |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=
*cite journal | author=Ito A, Kataoka TR, Watanabe M, "et al." |title=A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. |journal=EMBO J. |volume=19 |issue= 4 |pages= 562–71 |year= 2000 |pmid= 10675325 |doi= 10.1093/emboj/19.4.562
*cite journal | author=Ikeda S, Kishida M, Matsuura Y, "et al." |title=GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. |journal=Oncogene |volume=19 |issue= 4 |pages= 537–45 |year= 2000 |pmid= 10698523 |doi= 10.1038/sj.onc.1203359
*cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956–67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956
*cite journal | author=Elder RT, Yu M, Chen M, "et al." |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007
*cite journal | author=Muneer S, Ramalingam V, Wyatt R, "et al." |title=Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit. |journal=Genomics |volume=79 |issue= 3 |pages= 344–8 |year= 2002 |pmid= 11863364 |doi= 10.1006/geno.2002.6721
*cite journal | author=Strack S, Ruediger R, Walter G, "et al." |title=Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20750–5 |year= 2002 |pmid= 11929880 |doi= 10.1074/jbc.M202992200

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