HTR3A

5-hydroxytryptamine (serotonin) receptor 3A, also known as HTR3A, is a human gene.

PBB_Summary
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summary_text = The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3359| accessdate = ]

ee also

* 5-HT3 receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Miyake A, Mochizuki S, Takemoto Y, Akuzawa S |title=Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. |journal=Mol. Pharmacol. |volume=48 |issue= 3 |pages= 407–16 |year= 1995 |pmid= 7565620 |doi=
*cite journal | author=Uetz P, Abdelatty F, Villarroel A, "et al." |title=Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11. |journal=FEBS Lett. |volume=339 |issue= 3 |pages= 302–6 |year= 1994 |pmid= 8112471 |doi=
*cite journal | author=Weiss B, Mertz A, Schröck E, "et al." |title=Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2. |journal=Genomics |volume=29 |issue= 1 |pages= 304–5 |year= 1996 |pmid= 8530095 |doi= 10.1006/geno.1995.1254
*cite journal | author=Belelli D, Balcarek JM, Hope AG, "et al." |title=Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit. |journal=Mol. Pharmacol. |volume=48 |issue= 6 |pages= 1054–62 |year= 1996 |pmid= 8848005 |doi=
*cite journal | author=Brüss M, Göthert M, Hayer M, Bönisch H |title=Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs. |journal=Ann. N. Y. Acad. Sci. |volume=861 |issue= |pages= 234–5 |year= 1999 |pmid= 9928262 |doi=
*cite journal | author=Davies PA, Pistis M, Hanna MC, "et al." |title=The 5-HT3B subunit is a major determinant of serotonin-receptor function. |journal=Nature |volume=397 |issue= 6717 |pages= 359–63 |year= 1999 |pmid= 9950429 |doi= 10.1038/16941
*cite journal | author=Brüss M, Eucker T, Göthert M, Bönisch H |title=Exon-intron organization of the human 5-HT3A receptor gene. |journal=Neuropharmacology |volume=39 |issue= 2 |pages= 308–15 |year= 2000 |pmid= 10670426 |doi=
*cite journal | author=Marazziti D, Betti L, Giannaccini G, "et al." |title=Distribution of [3H] GR65630 binding in human brain postmortem. |journal=Neurochem. Res. |volume=26 |issue= 3 |pages= 187–90 |year= 2002 |pmid= 11495540 |doi=
*cite journal | author=Spier AD, Lummis SC |title=Immunological characterization of 5-HT3 receptor transmembrane topology. |journal=J. Mol. Neurosci. |volume=18 |issue= 3 |pages= 169–78 |year= 2003 |pmid= 12059035 |doi=
*cite journal | author=Boyd GW, Low P, Dunlop JI, "et al." |title=Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 1 |pages= 38–50 |year= 2002 |pmid= 12359150 |doi=
*cite journal | author=Hapfelmeier G, Haseneder R, Lampadius K, "et al." |title=Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics. |journal=Neurosci. Lett. |volume=335 |issue= 1 |pages= 44–8 |year= 2003 |pmid= 12457738 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pick H, Preuss AK, Mayer M, "et al." |title=Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells. |journal=Biochemistry |volume=42 |issue= 4 |pages= 877–84 |year= 2003 |pmid= 12549905 |doi= 10.1021/bi026576d
*cite journal | author=Choi S, Lee JH, Oh S, "et al." |title=Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. |journal=Mol. Cells |volume=15 |issue= 1 |pages= 108–13 |year= 2003 |pmid= 12661769 |doi=
*cite journal | author=Boyd GW, Doward AI, Kirkness EF, "et al." |title=Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27681–7 |year= 2003 |pmid= 12750374 |doi= 10.1074/jbc.M304938200
*cite journal | author=Sun H, Hu XQ, Moradel EM, "et al." |title=Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34150–7 |year= 2003 |pmid= 12791692 |doi= 10.1074/jbc.M303584200
*cite journal | author=Kelley SP, Dunlop JI, Kirkness EF, "et al." |title=A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. |journal=Nature |volume=424 |issue= 6946 |pages= 321–4 |year= 2003 |pmid= 12867984 |doi= 10.1038/nature01788
*cite journal | author=Maksay G, Bikádi Z, Simonyi M |title=Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models. |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 2-3 |pages= 255–70 |year= 2004 |pmid= 14626451 |doi=
*cite journal | author=Kaiser R, Tremblay PB, Sezer O, "et al." |title=Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists. |journal=Pharmacogenetics |volume=14 |issue= 5 |pages= 271–8 |year= 2004 |pmid= 15115912 |doi=
*cite journal | author=Panicker S, Cruz H, Arrabit C, "et al." |title=Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28149–58 |year= 2004 |pmid= 15131114 |doi= 10.1074/jbc.M403545200

External links

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