Proline dehydrogenase

In enzymology, a proline dehydrogenase (EC number|1.5.99.8) is an enzyme that catalyzes the chemical reaction

:L-proline + acceptor $ightleftharpoons$ (S)-1-pyrroline-5-carboxylate + reduced acceptor

Thus, the two substrates of this enzyme are L-proline and acceptor, whereas its two products are (S)-1-pyrroline-5-carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is L-proline:acceptor oxidoreductase. Other names in common use include L-proline dehydrogenase, and L-proline:(acceptor) oxidoreductase. This enzyme participates in arginine and proline metabolism. It employs one cofactor, FAD.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1K87, PDB link|1TIW, PDB link|1TJ0, PDB link|1TJ1, PDB link|1TJ2, PDB link|1Y56, PDB link|2FZM, PDB link|2FZN, and PDB link|2G37.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9050-70-8."

Gene Ontology (GO) codes