BUB1

BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast), also known as BUB1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.cite web | title = Entrez Gene: BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=699| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Pangilinan F, Li Q, Weaver T, "et al." |title=Mammalian BUB1 protein kinases: map positions and in vivo expression. |journal=Genomics |volume=46 |issue= 3 |pages= 379–88 |year= 1998 |pmid= 9441741 |doi= 10.1006/geno.1997.5068
*cite journal | author=Cahill DP, Lengauer C, Yu J, "et al." |title=Mutations of mitotic checkpoint genes in human cancers. |journal=Nature |volume=392 |issue= 6673 |pages= 300–3 |year= 1998 |pmid= 9521327 |doi= 10.1038/32688
*cite journal | author=Taylor SS, Ha E, McKeon F |title=The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. |journal=J. Cell Biol. |volume=142 |issue= 1 |pages= 1–11 |year= 1998 |pmid= 9660858 |doi=
*cite journal | author=Ouyang B, Lan Z, Meadows J, "et al." |title=Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation. |journal=Cell Growth Differ. |volume=9 |issue= 10 |pages= 877–85 |year= 1998 |pmid= 9790499 |doi=
*cite journal | author=Jablonski SA, Chan GK, Cooke CA, "et al." |title=The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. |journal=Chromosoma |volume=107 |issue= 6-7 |pages= 386–96 |year= 1999 |pmid= 9914370 |doi=
*cite journal | author=Seeley TW, Wang L, Zhen JY |title=Phosphorylation of human MAD1 by the BUB1 kinase in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 2 |pages= 589–95 |year= 1999 |pmid= 10198256 |doi= 10.1006/bbrc.1999.0514
*cite journal | author=Cahill DP, da Costa LT, Carson-Walter EB, "et al." |title=Characterization of MAD2B and other mitotic spindle checkpoint genes. |journal=Genomics |volume=58 |issue= 2 |pages= 181–7 |year= 1999 |pmid= 10366450 |doi= 10.1006/geno.1999.5831
*cite journal | author=Jaffrey RG, Pritchard SC, Clark C, "et al." |title=Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer. |journal=Cancer Res. |volume=60 |issue= 16 |pages= 4349–52 |year= 2000 |pmid= 10969775 |doi=
*cite journal | author=Steuerwald N, Cohen J, Herrera RJ, "et al." |title=Association between spindle assembly checkpoint expression and maternal age in human oocytes. |journal=Mol. Hum. Reprod. |volume=7 |issue= 1 |pages= 49–55 |year= 2001 |pmid= 11134360 |doi=
*cite journal | author=Kaplan KB, Burds AA, Swedlow JR, "et al." |title=A role for the Adenomatous Polyposis Coli protein in chromosome segregation. |journal=Nat. Cell Biol. |volume=3 |issue= 4 |pages= 429–32 |year= 2001 |pmid= 11283619 |doi= 10.1038/35070123
*cite journal | author=Wang X, Babu JR, Harden JM, "et al." |title=The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26559–67 |year= 2001 |pmid= 11352911 |doi= 10.1074/jbc.M101083200
*cite journal | author=Shichiri M, Yoshinaga K, Hisatomi H, "et al." |title=Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. |journal=Cancer Res. |volume=62 |issue= 1 |pages= 13–7 |year= 2002 |pmid= 11782350 |doi=
*cite journal | author=Taylor SS, Hussein D, Wang Y, "et al." |title=Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. |journal=J. Cell. Sci. |volume=114 |issue= Pt 24 |pages= 4385–95 |year= 2002 |pmid= 11792804 |doi=
*cite journal | author=Lin SF, Lin PM, Yang MC, "et al." |title=Expression of hBUB1 in acute myeloid leukemia. |journal=Leuk. Lymphoma |volume=43 |issue= 2 |pages= 385–91 |year= 2003 |pmid= 11999574 |doi=
*cite journal | author=Ru HY, Chen RL, Lu WC, Chen JH |title=hBUB1 defects in leukemia and lymphoma cells. |journal=Oncogene |volume=21 |issue= 30 |pages= 4673–9 |year= 2002 |pmid= 12096343 |doi= 10.1038/sj.onc.1205585
*cite journal | author=Nakagawa H, Yokozaki H, Oue N, "et al." |title=No mutations of the Bub1 gene in human gastric and oral cancer cell lines. |journal=Oncol. Rep. |volume=9 |issue= 6 |pages= 1229–32 |year= 2003 |pmid= 12375025 |doi=
*cite journal | author=Cayrol C, Cougoule C, Wright M |title=The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1. |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 5 |pages= 720–30 |year= 2003 |pmid= 12419313 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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