EIF4EBP1

Eukaryotic translation initiation factor 4E binding protein 1, also known as EIF4EBP1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.cite web | title = Entrez Gene: EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1978| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Armengol G, Rojo F, Castellví J, "et al." |title=4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications. |journal=Cancer Res. |volume=67 |issue= 16 |pages= 7551–5 |year= 2007 |pmid= 17699757 |doi= 10.1158/0008-5472.CAN-07-0881
*cite journal | author=Mader S, Lee H, Pause A, Sonenberg N |title=The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 4990–7 |year= 1995 |pmid= 7651417 |doi=
*cite journal | author=Pause A, Belsham GJ, Gingras AC, "et al." |title=Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. |journal=Nature |volume=371 |issue= 6500 |pages= 762–7 |year= 1994 |pmid= 7935836 |doi= 10.1038/371762a0
*cite journal | author=Haystead TA, Haystead CM, Hu C, "et al." |title=Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes. |journal=J. Biol. Chem. |volume=269 |issue= 37 |pages= 23185–91 |year= 1994 |pmid= 8083223 |doi=
*cite journal | author=Haghighat A, Mader S, Pause A, Sonenberg N |title=Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. |journal=EMBO J. |volume=14 |issue= 22 |pages= 5701–9 |year= 1996 |pmid= 8521827 |doi=
*cite journal | author=Feigenblum D, Schneider RJ |title=Cap-binding protein (eukaryotic initiation factor 4E) and 4E-inactivating protein BP-1 independently regulate cap-dependent translation. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5450–7 |year= 1996 |pmid= 8816458 |doi=
*cite journal | author=Rousseau D, Gingras AC, Pause A, Sonenberg N |title=The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. |journal=Oncogene |volume=13 |issue= 11 |pages= 2415–20 |year= 1997 |pmid= 8957083 |doi=
*cite journal | author=Tsukiyama-Kohara K, Vidal SM, Gingras AC, "et al." |title=Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. |journal=Genomics |volume=38 |issue= 3 |pages= 353–63 |year= 1997 |pmid= 8975712 |doi= 10.1006/geno.1996.0638
*cite journal | author=Fadden P, Haystead TA, Lawrence JC |title=Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10240–7 |year= 1997 |pmid= 9092573 |doi=
*cite journal | author=Brunn GJ, Fadden P, Haystead TA, Lawrence JC |title=The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32547–50 |year= 1998 |pmid= 9405468 |doi=
*cite journal | author=Burnett PE, Barrow RK, Cohen NA, "et al." |title=RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 4 |pages= 1432–7 |year= 1998 |pmid= 9465032 |doi=
*cite journal | author=New L, Jiang Y, Zhao M, "et al." |title=PRAK, a novel protein kinase regulated by the p38 MAP kinase. |journal=EMBO J. |volume=17 |issue= 12 |pages= 3372–84 |year= 1998 |pmid= 9628874 |doi= 10.1093/emboj/17.12.3372
*cite journal | author=Heesom KJ, Avison MB, Diggle TA, Denton RM |title=Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111). |journal=Biochem. J. |volume=336 ( Pt 1) |issue= |pages= 39–48 |year= 1999 |pmid= 9806882 |doi=
*cite journal | author=Waskiewicz AJ, Johnson JC, Penn B, "et al." |title=Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1871–80 |year= 1999 |pmid= 10022874 |doi=
*cite journal | author=Seeley TW, Wang L, Zhen JY |title=Phosphorylation of human MAD1 by the BUB1 kinase in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 2 |pages= 589–95 |year= 1999 |pmid= 10198256 |doi= 10.1006/bbrc.1999.0514
*cite journal | author=Gingras AC, Gygi SP, Raught B, "et al." |title=Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. |journal=Genes Dev. |volume=13 |issue= 11 |pages= 1422–37 |year= 1999 |pmid= 10364159 |doi=
*cite journal | author=Yang D, Brunn GJ, Lawrence JC |title=Mutational analysis of sites in the translational regulator, PHAS-I, that are selectively phosphorylated by mTOR. |journal=FEBS Lett. |volume=453 |issue= 3 |pages= 387–90 |year= 1999 |pmid= 10405182 |doi=
*cite journal | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538–43 |year= 2000 |pmid= 10608806 |doi=
*cite journal | author=Mothe-Satney I, Yang D, Fadden P, "et al." |title=Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3558–67 |year= 2000 |pmid= 10779345 |doi=
*cite journal | author=Mothe-Satney I, Brunn GJ, McMahon LP, "et al." |title=Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33836–43 |year= 2000 |pmid= 10942774 |doi= 10.1074/jbc.M006005200

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