Glutamate synthase (NADH)

Glutamate synthase (NADH)

In enzymology, a glutamate synthase (NADH) (EC number|1.4.1.14) is an enzyme that catalyzes the chemical reaction

:2 L-glutamate + NAD+ ightleftharpoons L-glutamine + 2-oxoglutarate + NADH + H+

Thus, the two substrates of this enzyme are L-glutamate and NAD+, whereas its 4 products are L-glutamine, 2-oxoglutarate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate:NAD+ oxidoreductase (transaminating). Other names in common use include glutamate (reduced nicotinamide adenine dinucleotide) synthase, NADH: GOGAT, L-glutamate synthase (NADH), L-glutamate synthetase, NADH-glutamate synthase, NADH-dependent glutamate synthase, and glutamate synthase (NADH). This enzyme participates in glutamate metabolism and nitrogen metabolism. It employs one cofactor, FMN.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|65589-88-0."

Gene Ontology (GO) codes


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