Glutamate synthase (ferredoxin)

In enzymology, a glutamate synthase (ferredoxin) (EC number|1.4.7.1) is an enzyme that catalyzes the chemical reaction

:2 L-glutamate + 2 oxidized ferredoxin $ightleftharpoons$ L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H⁺

Thus, the two substrates of this enzyme are L-glutamate and oxidized ferredoxin, whereas its 4 products are L-glutamine, 2-oxoglutarate, reduced ferredoxin, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is L-glutamate:ferredoxin oxidoreductase (transaminating). Other names in common use include ferredoxin-dependent glutamate synthase, ferredoxin-glutamate synthase, and glutamate synthase (ferredoxin-dependent). This enzyme participates in nitrogen metabolism. It has 5 cofactors: FAD, Iron, Sulfur, Iron-sulfur, and Flavoprotein.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1LLW, PDB link|1LLZ, PDB link|1LM1, PDB link|1OFD, and PDB link|1OFE.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|62213-56-3."

Gene Ontology (GO) codes