Aralkylamine dehydrogenase

In enzymology, an aralkylamine dehydrogenase (EC number|1.4.99.4) is an enzyme that catalyzes the chemical reaction

:RCH₂NH₂ + H₂O + acceptor $ightleftharpoons$ RCHO + NH₃ + reduced acceptor

The 3 substrates of this enzyme are RCH2NH2, H₂O, and acceptor, whereas its 3 products are RCHO, NH₃, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with other acceptors. The systematic name of this enzyme class is aralkylamine:acceptor oxidoreductase (deaminating). Other names in common use include aromatic amine dehydrogenase, dehydrogenase, arylamine, tyramine dehydrogenase, aromatic amine dehydrogenase, and aralkylamine:(acceptor) oxidoreductase (deaminating). This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

tructural studies

As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2AGL, PDB link|2AGW, PDB link|2AGX, PDB link|2AGY, PDB link|2AGZ, PDB link|2AH0, PDB link|2AH1, PDB link|2H3X, PDB link|2H47, PDB link|2HXC, PDB link|2I0R, PDB link|2I0S, PDB link|2I0T, PDB link|2IAA, PDB link|2IUP, PDB link|2IUQ, PDB link|2IUR, PDB link|2IUV, PDB link|2OIZ, PDB link|2OJY, PDB link|2OK4, PDB link|2OK6, and PDB link|2Q7Q.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|85030-73-5."

Gene Ontology (GO) codes