Amine oxidase (copper-containing)

In enzymology, an amine oxidase (copper-containing) (EC number|1.4.3.6) is an enzyme that catalyzes the chemical reaction

:RCH₂NH₂ + H₂O + O₂ $ightleftharpoons$ RCHO + NH₃ + H₂O₂

The 3 substrates of this enzyme are primary amines (RCH2NH2), H₂O, and O₂, whereas its 3 products are RCHO, NH₃, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is amine:oxygen oxidoreductase (deaminating) (copper-containing). Other names in common use include diamine oxidase, diamino oxhydrase, histaminase, amine oxidase, monoamine oxidase, amine oxidase (pyridoxal containing), benzylamine oxidase, histamine deaminase, histamine oxidase, Cu-amine oxidase, amine oxygen oxidoreductase, diamine:O2 oxidoreductase (deaminating), semicarbazide-sensitive amine oxidase, and SSAO. This enzyme participates in 8 metabolic pathways: urea cycle and metabolism of amino groups, glycine, serine and threonine metabolism, histidine metabolism, tyrosine metabolism, phenylalanine metabolism, tryptophan metabolism, beta-alanine metabolism, and alkaloid biosynthesis ii. It has 2 cofactors: copper, and PQQ.

tructural studies

As of late 2007, 51 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A2V, PDB link|1AV4, PDB link|1AVK, PDB link|1AVL, PDB link|1D6U, PDB link|1D6Y, PDB link|1D6Z, PDB link|1EKM, PDB link|1IQX, PDB link|1IQY, PDB link|1IU7, PDB link|1IVU, PDB link|1IVV, PDB link|1IVW, PDB link|1IVX, PDB link|1KSI, PDB link|1LVN, PDB link|1OAC, PDB link|1PU4, PDB link|1RJO, PDB link|1SIH, PDB link|1SII, PDB link|1SPU, PDB link|1TU5, PDB link|1UI7, PDB link|1UI8, PDB link|1US1, PDB link|1W2Z, PDB link|1W4N, PDB link|1W5Z, PDB link|1W6C, PDB link|1W6G, PDB link|1WMN, PDB link|1WMO, PDB link|1WMP, PDB link|2BT3, PDB link|2C10, PDB link|2C11, PDB link|2CFD, PDB link|2CFG, PDB link|2CFK, PDB link|2CFL, PDB link|2CFW, PDB link|2CG0, PDB link|2CG1, PDB link|2CWT, PDB link|2CWU, PDB link|2CWV, PDB link|2D1W, PDB link|2OOV, and PDB link|2OQE.

References

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* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 337-351.
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* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 313-335.

External links

::"The CAS registry number for this enzyme class is CAS registry|9001-53-0."

Gene Ontology (GO) codes