AP2M1

Adaptor-related protein complex 2, mu 1 subunit, also known as AP2M1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: AP2M1 adaptor-related protein complex 2, mu 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1173| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ohno H, Stewart J, Fournier MC, "et al." |title=Interaction of tyrosine-based sorting signals with clathrin-associated proteins. |journal=Science |volume=269 |issue= 5232 |pages= 1872–5 |year= 1995 |pmid= 7569928 |doi=
*cite journal | author=Nagase T, Miyajima N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37–43 |year= 1995 |pmid= 7788527 |doi=
*cite journal | author=Liu Q, Feng Y, Forgac M |title=Activity and in vitro reassembly of the coated vesicle (H+)-ATPase requires the 50-kDa subunit of the clathrin assembly complex AP-2. |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 31592–7 |year= 1995 |pmid= 7989329 |doi=
*cite journal | author=Pauloin A, Thurieau C |title=The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides. |journal=Biochem. J. |volume=296 ( Pt 2) |issue= |pages= 409–15 |year= 1994 |pmid= 8257432 |doi=
*cite journal | author=Chang MP, Mallet WG, Mostov KE, Brodsky FM |title=Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits. |journal=EMBO J. |volume=12 |issue= 5 |pages= 2169–80 |year= 1993 |pmid= 8491205 |doi=
*cite journal | author=Druck T, Gu Y, Prabhala G, "et al." |title=Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. |journal=Genomics |volume=30 |issue= 1 |pages= 94–7 |year= 1996 |pmid= 8595912 |doi= 10.1006/geno.1995.0016
*cite journal | author=Wang X, Kilimann MW |title=Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2. |journal=FEBS Lett. |volume=402 |issue= 1 |pages= 57–61 |year= 1997 |pmid= 9013859 |doi=
*cite journal | author=Chuang E, Alegre ML, Duckett CS, "et al." |title=Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. |journal=J. Immunol. |volume=159 |issue= 1 |pages= 144–51 |year= 1997 |pmid= 9200449 |doi=
*cite journal | author=Zhang Y, Allison JP |title=Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 17 |pages= 9273–8 |year= 1997 |pmid= 9256472 |doi=
*cite journal | author=Ohno H, Aguilar RC, Fournier MC, "et al." |title=Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family. |journal=Virology |volume=238 |issue= 2 |pages= 305–15 |year= 1998 |pmid= 9400603 |doi= 10.1006/viro.1997.8839
*cite journal | author=Santini F, Marks MS, Keen JH |title=Endocytic clathrin-coated pit formation is independent of receptor internalization signal levels. |journal=Mol. Biol. Cell |volume=9 |issue= 5 |pages= 1177–94 |year= 1998 |pmid= 9571248 |doi=
*cite journal | author=Owen DJ, Evans PR |title=A structural explanation for the recognition of tyrosine-based endocytotic signals. |journal=Science |volume=282 |issue= 5392 |pages= 1327–32 |year= 1998 |pmid= 9812899 |doi=
*cite journal | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, "et al." |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350–61 |year= 1999 |pmid= 9882340 |doi=
*cite journal | author=Teuchert M, Berghöfer S, Klenk HD, Garten W |title=Recycling of furin from the plasma membrane. Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36781–9 |year= 2000 |pmid= 10593987 |doi=
*cite journal | author=Umeda A, Meyerholz A, Ungewickell E |title=Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation. |journal=Eur. J. Cell Biol. |volume=79 |issue= 5 |pages= 336–42 |year= 2000 |pmid= 10887964 |doi=
*cite journal | author=Jullien-Flores V, Mahé Y, Mirey G, "et al." |title=RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. |journal=J. Cell. Sci. |volume=113 ( Pt 16) |issue= |pages= 2837–44 |year= 2000 |pmid= 10910768 |doi=
*cite journal | author=Wyss S, Berlioz-Torrent C, Boge M, "et al." |title=The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter] . |journal=J. Virol. |volume=75 |issue= 6 |pages= 2982–92 |year= 2001 |pmid= 11222723 |doi= 10.1128/JVI.75.6.2982-2992.2001
*cite journal | author=Morris SM, Cooper JA |title=Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. |journal=Traffic |volume=2 |issue= 2 |pages= 111–23 |year= 2001 |pmid= 11247302 |doi=
*cite journal | author=Follows ER, McPheat JC, Minshull C, "et al." |title=Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28. |journal=Biochem. J. |volume=359 |issue= Pt 2 |pages= 427–34 |year= 2001 |pmid= 11583591 |doi=
*cite journal | author=Friocourt G, Chafey P, Billuart P, "et al." |title=Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system. |journal=Mol. Cell. Neurosci. |volume=18 |issue= 3 |pages= 307–19 |year= 2001 |pmid= 11591131 |doi= 10.1006/mcne.2001.1022

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