GGA1

Golgi associated, gamma adaptin ear containing, ARF binding protein 1, also known as GGA1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26088| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Hirst J, Lui WW, Bright NA, "et al." |title=A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 67–80 |year= 2000 |pmid= 10747088 |doi=
*cite journal | author=Dell'Angelica EC, Puertollano R, Mullins C, "et al." |title=GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 81–94 |year= 2000 |pmid= 10747089 |doi=
*cite journal | author=Boman AL, Zhang C, Zhu X, Kahn RA |title=A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi. |journal=Mol. Biol. Cell |volume=11 |issue= 4 |pages= 1241–55 |year= 2000 |pmid= 10749927 |doi=
*cite journal | author=Takatsu H, Yoshino K, Nakayama K |title=Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 3 |pages= 719–25 |year= 2000 |pmid= 10814529 |doi= 10.1006/bbrc.2000.2700
*cite journal | author=Zhdankina O, Strand NL, Redmond JM, Boman AL |title=Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi. |journal=Yeast |volume=18 |issue= 1 |pages= 1–18 |year= 2001 |pmid= 11124697 |doi= 10.1002/1097-0061(200101)18:1<1::AID-YEA644>3.0.CO;2-5 |doilabel=10.1002/1097-0061(200101)18:11::AID-YEA6443.0.CO;2-5
*cite journal | author=Puertollano R, Randazzo PA, Presley JF, "et al." |title=The GGAs promote ARF-dependent recruitment of clathrin to the TGN. |journal=Cell |volume=105 |issue= 1 |pages= 93–102 |year= 2001 |pmid= 11301005 |doi=
*cite journal | author=Puertollano R, Aguilar RC, Gorshkova I, "et al." |title=Sorting of mannose 6-phosphate receptors mediated by the GGAs. |journal=Science |volume=292 |issue= 5522 |pages= 1712–6 |year= 2001 |pmid= 11387475 |doi= 10.1126/science.1060750
*cite journal | author=Takatsu H, Katoh Y, Shiba Y, Nakayama K |title=Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28541–5 |year= 2001 |pmid= 11390366 |doi= 10.1074/jbc.C100218200
*cite journal | author=Jacobsen L, Madsen P, Nielsen MS, "et al." |title=The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. |journal=FEBS Lett. |volume=511 |issue= 1-3 |pages= 155–8 |year= 2002 |pmid= 11821067 |doi=
*cite journal | author=Shiba T, Takatsu H, Nogi T, "et al." |title=Structural basis for recognition of acidic-cluster dileucine sequence by GGA1. |journal=Nature |volume=415 |issue= 6874 |pages= 937–41 |year= 2002 |pmid= 11859376 |doi= 10.1038/415937a
*cite journal | author=Takatsu H, Yoshino K, Toda K, Nakayama K |title=GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 369–78 |year= 2002 |pmid= 11950392 |doi= 10.1042/BJ20020428
*cite journal | author=Doray B, Bruns K, Ghosh P, Kornfeld SA |title=Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8072–7 |year= 2002 |pmid= 12060753 |doi= 10.1073/pnas.082235699
*cite journal | author=He X, Chang WP, Koelsch G, Tang J |title=Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. |journal=FEBS Lett. |volume=524 |issue= 1-3 |pages= 183–7 |year= 2002 |pmid= 12135764 |doi=
*cite journal | author=Boman AL, Salo PD, Hauglund MJ, "et al." |title=ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization. |journal=Mol. Biol. Cell |volume=13 |issue= 9 |pages= 3078–95 |year= 2003 |pmid= 12221117 |doi= 10.1091/mbc.E02-02-0078
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mattera R, Arighi CN, Lodge R, "et al." |title=Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. |journal=EMBO J. |volume=22 |issue= 1 |pages= 78–88 |year= 2003 |pmid= 12505986 |doi= 10.1093/emboj/cdg015
*cite journal | author=Mills IG, Praefcke GJ, Vallis Y, "et al." |title=EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. |journal=J. Cell Biol. |volume=160 |issue= 2 |pages= 213–22 |year= 2003 |pmid= 12538641 |doi= 10.1083/jcb.200208023

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