Sortilin 1

Sortilin 1, also known as SORT1, is a human gene.cite web | title = Entrez Gene: SORT1 sortilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6272| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.cite web | title = Entrez Gene: SORT1 sortilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6272| accessdate = ]

ee also

* Neurotensin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Vincent JP, Mazella J, Kitabgi P |title=Neurotensin and neurotensin receptors. |journal=Trends Pharmacol. Sci. |volume=20 |issue= 7 |pages= 302–9 |year= 1999 |pmid= 10390649 |doi=
*cite journal | author=Mazella J |title=Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking? |journal=Cell. Signal. |volume=13 |issue= 1 |pages= 1–6 |year= 2001 |pmid= 11257441 |doi=
*cite journal | author=Petersen CM, Nielsen MS, Nykjaer A, "et al." |title=Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3599–605 |year= 1997 |pmid= 9013611 |doi=
*cite journal | author=Lin BZ, Pilch PF, Kandror KV |title=Sortilin is a major protein component of Glut4-containing vesicles. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24145–7 |year= 1997 |pmid= 9305862 |doi=
*cite journal | author=Tauris J, Ellgaard L, Jacobsen C, "et al." |title=The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin. |journal=FEBS Lett. |volume=429 |issue= 1 |pages= 27–30 |year= 1998 |pmid= 9657377 |doi=
*cite journal | author=Mazella J, Zsürger N, Navarro V, "et al." |title=The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26273–6 |year= 1998 |pmid= 9756851 |doi=
*cite journal | author=Munck Petersen C, Nielsen MS, Jacobsen C, "et al." |title=Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding. |journal=EMBO J. |volume=18 |issue= 3 |pages= 595–604 |year= 1999 |pmid= 9927419 |doi= 10.1093/emboj/18.3.595
*cite journal | author=Nielsen MS, Jacobsen C, Olivecrona G, "et al." |title=Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8832–6 |year= 1999 |pmid= 10085125 |doi=
*cite journal | author=Nielsen MS, Madsen P, Christensen EI, "et al." |title=The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2180–90 |year= 2001 |pmid= 11331584 |doi= 10.1093/emboj/20.9.2180
*cite journal | author=Takatsu H, Katoh Y, Shiba Y, Nakayama K |title=Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28541–5 |year= 2001 |pmid= 11390366 |doi= 10.1074/jbc.C100218200
*cite journal | author=Hampe W, Rezgaoui M, Hermans-Borgmeyer I, Schaller HC |title=The genes for the human VPS10 domain-containing receptors are large and contain many small exons. |journal=Hum. Genet. |volume=108 |issue= 6 |pages= 529–36 |year= 2001 |pmid= 11499680 |doi=
*cite journal | author=Shiba T, Takatsu H, Nogi T, "et al." |title=Structural basis for recognition of acidic-cluster dileucine sequence by GGA1. |journal=Nature |volume=415 |issue= 6874 |pages= 937–41 |year= 2002 |pmid= 11859376 |doi= 10.1038/415937a
*cite journal | author=Maeda S, Nobukuni T, Shimo-Onoda K, "et al." |title=Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization. |journal=J. Cell. Physiol. |volume=193 |issue= 1 |pages= 73–9 |year= 2002 |pmid= 12209882 |doi= 10.1002/jcp.10151
*cite journal | author=Martin S, Navarro V, Vincent JP, Mazella J |title=Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line. |journal=Gastroenterology |volume=123 |issue= 4 |pages= 1135–43 |year= 2002 |pmid= 12360476 |doi=
*cite journal | author=Navarro V, Vincent JP, Mazella J |title=Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line. |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 5 |pages= 760–4 |year= 2003 |pmid= 12419319 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Martin S, Vincent JP, Mazella J |title=Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia. |journal=J. Neurosci. |volume=23 |issue= 4 |pages= 1198–205 |year= 2003 |pmid= 12598608 |doi=
*cite journal | author=Lefrancois S, Zeng J, Hassan AJ, "et al." |title=The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6430–7 |year= 2004 |pmid= 14657016 |doi= 10.1093/emboj/cdg629

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