GGA2

Golgi associated, gamma adaptin ear containing, ARF binding protein 2, also known as GGA2, is a human gene.cite web | title = Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23062| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.cite web | title = Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23062| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=
*cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, "et al." |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927
*cite journal | author=Poussu A, Lohi O, Lehto VP |title=Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7176–83 |year= 2000 |pmid= 10702286 |doi=
*cite journal | author=Hirst J, Lui WW, Bright NA, "et al." |title=A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 67–80 |year= 2000 |pmid= 10747088 |doi=
*cite journal | author=Dell'Angelica EC, Puertollano R, Mullins C, "et al." |title=GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 81–94 |year= 2000 |pmid= 10747089 |doi=
*cite journal | author=Boman AL, Zhang C, Zhu X, Kahn RA |title=A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi. |journal=Mol. Biol. Cell |volume=11 |issue= 4 |pages= 1241–55 |year= 2000 |pmid= 10749927 |doi=
*cite journal | author=Takatsu H, Yoshino K, Nakayama K |title=Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 3 |pages= 719–25 |year= 2000 |pmid= 10814529 |doi= 10.1006/bbrc.2000.2700
*cite journal | author=Puertollano R, Randazzo PA, Presley JF, "et al." |title=The GGAs promote ARF-dependent recruitment of clathrin to the TGN. |journal=Cell |volume=105 |issue= 1 |pages= 93–102 |year= 2001 |pmid= 11301005 |doi=
*cite journal | author=Nielsen MS, Madsen P, Christensen EI, "et al." |title=The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2180–90 |year= 2001 |pmid= 11331584 |doi= 10.1093/emboj/20.9.2180
*cite journal | author=Puertollano R, Aguilar RC, Gorshkova I, "et al." |title=Sorting of mannose 6-phosphate receptors mediated by the GGAs. |journal=Science |volume=292 |issue= 5522 |pages= 1712–6 |year= 2001 |pmid= 11387475 |doi= 10.1126/science.1060750
*cite journal | author=Zhu Y, Doray B, Poussu A, "et al." |title=Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor. |journal=Science |volume=292 |issue= 5522 |pages= 1716–8 |year= 2001 |pmid= 11387476 |doi= 10.1126/science.1060896
*cite journal | author=Takatsu H, Katoh Y, Shiba Y, Nakayama K |title=Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28541–5 |year= 2001 |pmid= 11390366 |doi= 10.1074/jbc.C100218200
*cite journal | author=Jacobsen L, Madsen P, Nielsen MS, "et al." |title=The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. |journal=FEBS Lett. |volume=511 |issue= 1-3 |pages= 155–8 |year= 2002 |pmid= 11821067 |doi=
*cite journal | author=Doray B, Bruns K, Ghosh P, Kornfeld S |title=Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18477–82 |year= 2002 |pmid= 11886874 |doi= 10.1074/jbc.M201879200
*cite journal | author=Takatsu H, Yoshino K, Toda K, Nakayama K |title=GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 369–78 |year= 2002 |pmid= 11950392 |doi= 10.1042/BJ20020428
*cite journal | author=He X, Chang WP, Koelsch G, Tang J |title=Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. |journal=FEBS Lett. |volume=524 |issue= 1-3 |pages= 183–7 |year= 2002 |pmid= 12135764 |doi=
*cite journal | author=Wasiak S, Legendre-Guillemin V, Puertollano R, "et al." |title=Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. |journal=J. Cell Biol. |volume=158 |issue= 5 |pages= 855–62 |year= 2002 |pmid= 12213833 |doi= 10.1083/jcb.200205078
*cite journal | author=Kalthoff C, Groos S, Kohl R, "et al." |title=Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4060–73 |year= 2003 |pmid= 12429846 |doi= 10.1091/mbc.E02-03-0171
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes