Protocatechuate 3,4-dioxygenase

In enzymology, a protocatechuate 3,4-dioxygenase (EC number|1.13.11.3) is an enzyme that catalyzes the chemical reaction

:3,4-dihydroxybenzoate + O₂ $ightleftharpoons$ 3-carboxy-cis,cis-muconate

Thus, the two substrates of this enzyme are 3,4-dihydroxybenzoate and O₂, whereas its product is 3-carboxy-cis,cis-muconate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is protocatechuate:oxygen 3,4-oxidoreductase (decyclizing). Other names in common use include protocatechuate oxygenase, protocatechuic acid oxidase, protocatechuic 3,4-dioxygenase, and protocatechuic 3,4-oxygenase. This enzyme participates in benzoate degradation via hydroxylation and 2,4-dichlorobenzoate degradation. It employs one cofactor, iron.

tructural studies

As of late 2007, 37 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EO2, PDB link|1EO9, PDB link|1EOA, PDB link|1EOB, PDB link|1EOC, PDB link|1YKK, PDB link|1YKL, PDB link|1YKM, PDB link|1YKN, PDB link|1YKO, PDB link|1YKP, PDB link|2BUM, PDB link|2BUQ, PDB link|2BUR, PDB link|2BUT, PDB link|2BUU, PDB link|2BUV, PDB link|2BUW, PDB link|2BUX, PDB link|2BUY, PDB link|2BUZ, PDB link|2BV0, PDB link|2PCD, PDB link|3PCA, PDB link|3PCB, PDB link|3PCC, PDB link|3PCD, PDB link|3PCE, PDB link|3PCF, PDB link|3PCG, PDB link|3PCH, PDB link|3PCI, PDB link|3PCJ, PDB link|3PCK, PDB link|3PCL, PDB link|3PCM, and PDB link|3PCN.

ee also

* protocatechuic acid

References

*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9029-47-4."

Gene Ontology (GO) codes