- Catechol dioxygenase
Catechol dioxygenases are
metalloprotein enzyme s that carry out the oxidative cleavage ofcatechol s. This class of enzymes incorporatedioxygen into thesubstrate (biochemistry) . Catechol dioxygenases belong to the class ofoxidoreductase s and have several different substrate specificities, including catechol 1,2-dioxygenase (EC number|1.13.11.1), catechol 2,3-dioxygenase (EC number|1.13.11.2), and protocatechuate 3,4-dioxygenase (EC number|1.13.11.3). The active site of catechol dioxygenases most frequently containsiron , butmanganese -containing forms are also known.The "
Pseudomonas putida " xylE gene, which encodes catechol 2,3-dioxygenase, is often used as a reporter to quantitate gene expression.An example of the reaction carried out by catechol 1,2-dioxygenase is the formation of "cis,cis"-muconic acid from
catechol , shown below.ee also
*
Bioinorganic chemistry
*Oxygenase References
* Stephen J. Lippard, Jeremy M. Berg, "Principles of Bioinorganic Chemistry", University Science Books, 1994, ISBN 0-935702-72-5
* J.J.R. Fraústo da Silva and R.J.P. Williams, "The biological chemistry of the elements: The inorganic chemistry of life", 2nd Edition, Oxford University Press, 2001, ISBN 0-19-850848-4
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