- Chloridazon-catechol dioxygenase
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chloridazon-catechol dioxygenase Identifiers EC number 1.13.11.36 CAS number 82869-32-7 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a chloridazon-catechol dioxygenase (EC 1.13.11.36) is an enzyme that catalyzes the chemical reaction
- 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + O2 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone
Thus, the two substrates of this enzyme are 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone and O2, whereas its product is 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone.
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing). It employs one cofactor, iron.
References
- Muller R, Haug S, Eberspacher J, Lingens F (1977). "[Catechol 2,3-dioxygenase from pyrazon-degrading bacteria (author's transl)]". Hoppe. Seylers. Z. Physiol. Chem. 358 (7): 797–805. PMID 19349.
- Muller R, Schmitt S, Lingens F (1982). "A novel non-heme iron-containing dioxygenase. Chloridazon-catechol dioxygenase from Phenylobacterium immobilis DSM 1986". Eur. J. Biochem. 125 (3): 579–84. doi:10.1111/j.1432-1033.1982.tb06722.x. PMID 6811270.
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