Chloridazon-catechol dioxygenase

Chloridazon-catechol dioxygenase
chloridazon-catechol dioxygenase
Identifiers
EC number 1.13.11.36
CAS number 82869-32-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a chloridazon-catechol dioxygenase (EC 1.13.11.36) is an enzyme that catalyzes the chemical reaction

5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + O2 \rightleftharpoons 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone

Thus, the two substrates of this enzyme are 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone and O2, whereas its product is 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing). It employs one cofactor, iron.

References

  • Muller R, Haug S, Eberspacher J, Lingens F (1977). "[Catechol 2,3-dioxygenase from pyrazon-degrading bacteria (author's transl)]". Hoppe. Seylers. Z. Physiol. Chem. 358 (7): 797–805. PMID 19349. 
  • Muller R, Schmitt S, Lingens F (1982). "A novel non-heme iron-containing dioxygenase. Chloridazon-catechol dioxygenase from Phenylobacterium immobilis DSM 1986". Eur. J. Biochem. 125 (3): 579–84. doi:10.1111/j.1432-1033.1982.tb06722.x. PMID 6811270. 
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