Biphenyl-2,3-diol 1,2-dioxygenase

In enzymology, a biphenyl-2,3-diol 1,2-dioxygenase (EC number|1.13.11.39) is an enzyme that catalyzes the chemical reaction

:biphenyl-2,3-diol + O₂ $ightleftharpoons$ 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H₂O

Thus, the two substrates of this enzyme are biphenyl-2,3-diol and O₂, whereas its two products are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include 2,3-dihydroxybiphenyl dioxygenase, and biphenyl-2,3-diol dioxygenase. This enzyme participates in gamma-hexachlorocyclohexane degradation and biphenyl degradation.

tructural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DHY, PDB link|1EIL, PDB link|1EIQ, PDB link|1EIR, PDB link|1HAN, PDB link|1KMY, PDB link|1KND, PDB link|1KNF, PDB link|1KW3, PDB link|1KW6, PDB link|1KW8, PDB link|1KW9, PDB link|1KWB, PDB link|1KWC, PDB link|1LGT, and PDB link|1LKD.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|103679-58-9."

Gene Ontology (GO) codes