Glycolaldehyde dehydrogenase

In enzymology, a glycolaldehyde dehydrogenase (EC number|1.2.1.21) is an enzyme that catalyzes the chemical reaction

:glycolaldehyde + NAD⁺ + H₂O $ightleftharpoons$ glycolate + NADH + 2 H⁺

The 3 substrates of this enzyme are glycolaldehyde, NAD⁺, and H₂O, whereas its 3 products are glycolate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolaldehyde:NAD+ oxidoreductase. This enzyme is also called glycol aldehyde dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2HG2, PDB link|2ILU, and PDB link|2IMP.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37250-89-8."

Gene Ontology (GO) codes