Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

In enzymology, a glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) (EC number|1.2.1.13) is an enzyme that catalyzes the chemical reaction

:D-glyceraldehyde 3-phosphate + phosphate + NADP⁺ $ightleftharpoons$ 3-phospho-D-glyceroyl phosphate + NADPH + H⁺

The 3 substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate, and NADP⁺, whereas its 3 products are 3-phospho-D-glyceroyl phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating). Other names in common use include triosephosphate dehydrogenase (NADP+), dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine, dinucleotide phosphate) (phosphorylating), glyceraldehyde phosphate dehydrogenase (nicotinamide adenine, dinucleotide phosphate) (phosphorylating), NADP+-glyceraldehyde-3-phosphate dehydrogenase, NADP+-glyceraldehyde phosphate dehydrogenase, NADP+-dependent glyceraldehyde phosphate dehydrogenase, NADP+-triose phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating), and GAPDH. This enzyme participates in carbon fixation.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1JN0, PDB link|1NBO, PDB link|1RM3, PDB link|1RM4, PDB link|1RM5, PDB link|2D2I, PDB link|2DUU, PDB link|2HKI, PDB link|2PKQ, and PDB link|2PKR.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37250-87-6."

Gene Ontology (GO) codes