4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase

In enzymology, a 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase (EC number|1.2.1.45) is an enzyme that catalyzes the chemical reaction

:4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP⁺ + H₂O $ightleftharpoons$ 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + 2 H⁺

The 3 substrates of this enzyme are 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde, NADP⁺, and H₂O, whereas its 3 products are 4-carboxy-2-hydroxy-cis,cis-muconate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase. Other names in common use include 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+, oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde, and dehydrogenase. This enzyme participates in tyrosine metabolism and benzoate degradation via hydroxylation.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|67272-39-3."

Gene Ontology (GO) codes