Deoxyhypusine monooxygenase

Deoxyhypusine monooxygenase
deoxyhypusine monooxygenase
Identifiers
EC number 1.14.99.29
CAS number 101920-83-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a deoxyhypusine monooxygenase (EC 1.14.99.29) is an enzyme that catalyzes the chemical reaction

protein N6-(4-aminobutyl)-L-lysine + AH2 + O2 \rightleftharpoons protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H2O

The 3 substrates of this enzyme are a protein-bound N6-(4-aminobutyl)-L-lysine, an electron acceptor AH2, and O2, and its 3 products are protein-bound N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine, the reduction product A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating). Other names in common use include deoxyhypusine hydroxylase, and deoxyhypusine dioxygenase.

References

  • Abbruzzese A, Park MH, Folk JE (1986). "Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization". J. Biol. Chem. 261 (7): 3085–9. PMID 3949761. 
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