Isovaleryl-CoA dehydrogenase
- Isovaleryl-CoA dehydrogenase
In enzymology, an isovaleryl-CoA dehydrogenase (EC number|1.3.99.10) is an enzyme that catalyzes the chemical reaction
:3-methylbutanoyl-CoA + acceptor 3-methylbut-2-enoyl-CoA + reduced acceptor
Thus, the two substrates of this enzyme are 3-methylbutanoyl-CoA and acceptor, whereas its two products are 3-methylbut-2-enoyl-CoA and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-methylbutanoyl-CoA:acceptor oxidoreductase. Other names in common use include isovaleryl-coenzyme A dehydrogenase, isovaleroyl-coenzyme A dehydrogenase, and 3-methylbutanoyl-CoA:(acceptor) oxidoreductase. This enzyme participates in valine, leucine and isoleucine degradation. It employs one cofactor, FAD.
tructural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1IVH.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|37274-61-6."
Gene Ontology (GO) codes
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2010.
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isovaleryl-CoA dehydrogenase — iso·val·er·yl CoA de·hy·dro·gen·ase (i″so və lerґəl ko aґ de hiґdro jən ās) [EC 1.3.99.10] an enzyme of the oxidoreductase class that catalyzes the dehydrogenation of isovaleryl CoA to 3 methylcrotonyl CoA, using… … Medical dictionary
isovaleryl-CoA — The condensation product of isovaleric acid and coenzyme A; an intermediate in the catabolism of l leucine. SYN: isovalerylcoenzyme A. isovaleryl CoA dehydrogenase an enzyme that participates in the catabolism of l leucine; it converts isovaleryl … Medical dictionary
Isovaleryl-CoA — Chembox new ImageFile=Isovaleryl coenzyme A.svg ImageSize=300px IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=6244 91 3 PubChem=810 SMILES= MeSHName=isovaleryl coenzyme+A Section2= Chembox Properties Formula=C26H44N7O17P3S… … Wikipedia
Isovaleryl coenzyme A dehydrogenase — protein Name=isovaleryl Coenzyme A dehydrogenase caption= width= HGNCid=6186 Symbol=IVD AltSymbols= EntrezGene=3712 OMIM=607036 RefSeq=NM 002225 UniProt=P26440 PDB= ECnumber=1.3.99.10 Chromosome=15 Arm=q Band=14 LocusSupplementaryData=… … Wikipedia
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