Cucurbitacin Delta23-reductase

Cucurbitacin Delta23-reductase
cucurbitacin delta23-reductase
Identifiers
EC number 1.3.1.5
CAS number 37256-38-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cucurbitacin Delta23-reductase (EC 1.3.1.5) is an enzyme that catalyzes the chemical reaction

23,24-dihydrocucurbitacin + NAD(P)+ \rightleftharpoons cucurbitacin + NAD(P)H + H+

The 3 substrates of this enzyme are 23,24-dihydrocucurbitacin, NAD+, and NADP+, whereas its 4 products are cucurbitacin, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 23,24-dihydrocucurbitacin:NAD(P)+ Delta23-oxidoreductase. This enzyme is also called NAD(P)H: cucurbitacin B Delta23-oxidoreductase. It employs one cofactor, manganese.

References

  • Schabort JC, Potgieter DJ (1968). "Cucurbitacin B delta 23-reductase from Cucurbita maxima. II Cofactor requirements, enzyme kinetics, substrate specificity and other characteristics". Biochim. Biophys. Acta. 151 (1): 47–53. PMID 4384331. 
  • Schabort JC, Potgieter DJ, de Villiers V (1968). "Cucurbitacin B delta 23-reductase from Cucurbita maxima. I. Assay methods, isolation and purification". Biochim. Biophys. Acta. 151 (1): 33–46. PMID 5640163. 
This EC 1.3 enzyme-related article is a stub. You can help Wikipedia by expanding it.