Cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase

Cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase

cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase

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In enzymology, a cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase (EC 1.3.1.67) is an enzyme that catalyzes the chemical reaction

cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD(P)+ $\rightleftharpoons$ 4-methylcatechol + NAD(P)H + CO₂

The 3 substrates of this enzyme are cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate, NAD⁺, and NADP⁺, whereas its 4 products are 4-methylcatechol, NADH, NADPH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating). This enzyme participates in toluene and xylene degradation.

References

Whited GM, McCombie WR, Kwart LD, Gibson DT (1986). "Identification of cis-diols as intermediates in the oxidation of aromatic acids by a strain of Pseudomonas putida that contains a TOL plasmid". J. Bacteriol. 166 (3): 1028–39. PMC 215228. PMID 3711022. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=215228.

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