TRNA (guanine-N2-)-methyltransferase

In enzymology, a tRNA (guanine-N2-)-methyltransferase (EC number|2.1.1.32) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + tRNA $ightleftharpoons$ S-adenosyl-L-homocysteine + tRNA containing N₂-methylguanine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N2-methylguanine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase. Other names in common use include transfer ribonucleate guanine 2-methyltransferase, transfer ribonucleate guanine N2-methyltransferase, transfer RNA guanine 2-methyltransferase, guanine-N2-methylase, and S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2DUL, PDB link|2EJT, and PDB link|2EJU.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37217-31-5."

Gene Ontology (GO) codes