TRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase

In enzymology, a tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC number|2.1.1.61) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + tRNA $ightleftharpoons$ S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing 5-methylaminomethyl-2-thiouridylic acid.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase. Other names in common use include transfer ribonucleate 5-methylaminomethyl-2-thiouridylate, 5-methyltransferase, and tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2DER, PDB link|2DET, PDB link|2DEU, and PDB link|2HMA.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|39391-17-8."

Gene Ontology (GO) codes