Deoxycytidylate C-methyltransferase

Deoxycytidylate C-methyltransferase
deoxycytidylate C-methyltransferase
Identifiers
EC number 2.1.1.54
CAS number 61970-01-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a deoxycytidylate C-methyltransferase (EC 2.1.1.54) is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydrofolate + dCMP \rightleftharpoons dihydrofolate + deoxy-5-methylcytidylate

Thus, the two substrates of this enzyme are 5,10-methylenetetrahydrofolic acid and dCMP, whereas its two products are dihydrofolic acid and deoxy-5-methylcytidylic acid.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:dCMP C-methyltransferase. Other names in common use include deoxycytidylate methyltransferase, and dCMP methyltransferase.

References

  • Kuo TT, Tu J (1976). "Enzymatic synthesis of deoxy-5-methyl-cytidylic acid replacing deoxycytidylic acid in Xanthomonas oryzae phage Xp12DNA". Nature. 263 (5578): 615. doi:10.1038/263615a0. PMID 980110. 
This transferase article is a stub. You can help Wikipedia by expanding it.