UDP-N-acetylglucosamine

UDP-N-acetylglucosamine

UDP-N-acetylglucosamine or UDP-GlcNAc is a nucleotide sugar and a coenzyme in metabolism. It is used by glycosyltransferases to transfer N-acetylglucosamine residues to substrates. D-Glucosamine is made naturally in the form of glucosamine-6-phosphate, and is the biochemical precursor of all nitrogen-containing sugars. [Roseman S. "Reflections on glycobiology," "J Biol Chem", 2001 November 9; 276(45):41527-42. PMID 11553646. [http://www.jbc.org/cgi/content/full/276/45/41527 Full Text Online] ] Specifically, glucosamine-6-phosphate is synthesized from fructose-6-phosphate and glutamine [Ghosh S, Blumenthal HJ, Davidson E, Roseman S. "Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate", "J Biol Chem", 1960 May; . PMID 13827775. [http://www.jbc.org/cgi/reprint/235/5/1265 PDF online] .] as the first step of the hexosamine biosynthesis pathway. [ [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPGlcN.html International Union of Biochemistry and Molecular Biology] ] The end-product of this pathway is UDP-N-acetylglucosamine (UDP-GlcNAc), which is then used for making glycosaminoglycans, proteoglycans, and glycolipids. [cite journal |author=Milewski S, Gabriel I, Olchowy J |title=Enzymes of UDP-GlcNAc biosynthesis in yeast |journal=Yeast |volume=23 |issue=1 |pages=1–14 |year=2006 |pmid=16408321 |doi=10.1002/yea.1337]

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • UDP-N-acetylglucosamine pyrophosphorylase — UDP N ac·e·tyl·glu·co·sa·mine py·ro·phos·phor·y·lase (as″ə tēl″gloo kōsґə mēn pi″ro fos forґə lās) [EC 2.7.7.23] an enzyme of the transferase class that catalyzes the attachment of a UMP group… …   Medical dictionary

  • UDP-N-acetylglucosamine 4-epimerase — UDP N ac·e·tyl·glu·co·sa·mine 4 epim·er·ase (as″ə tēl″gloo kōsґə mēn ə pimґə rās) [EC 5.1.3.7] an enzyme of the isomerase class that catalyzes the interconversion of the epimers UDP N… …   Medical dictionary

  • UDP-N-acetylglucosamine — UDP N ac·e·tyl·glu·co·sa·mine (as″ə tēl″gloo kōsґə mēn) a nucleotide derivative of N acetylglucosamine; it donates acetylglucosamine groups in the synthesis of glycosaminoglycans and is the parent compound for …   Medical dictionary

  • UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase — In enzymology, an UDP N acetylglucosamine lysosomal enzyme N acetylglucosaminephosphotransferase (EC number|2.7.8.17) is an enzyme that catalyzes the chemical reaction:UDP N acetyl D glucosamine + lysosomal enzyme D mannose ightleftharpoons UMP + …   Wikipedia

  • UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase — In enzymology, an UDP N acetylglucosamine dolichyl phosphate N acetylglucosaminephosphotransferase (EC number|2.7.8.15) is an enzyme that catalyzes the chemical reaction:UDP N acetyl D glucosamine + dolichyl phosphate ightleftharpoons UMP + N… …   Wikipedia

  • UDP-N-acetylglucosamine 1-carboxyvinyltransferase — In enzymology, an UDP N acetylglucosamine 1 carboxyvinyltransferase (EC number|2.5.1.7) is an enzyme that catalyzes the chemical reaction:phosphoenolpyruvate + UDP N acetyl D glucosamine ightleftharpoons phosphate + UDP N acetyl 3 O (1… …   Wikipedia

  • UDP-N-acetylglucosamine diphosphorylase — In enzymology, an UDP N acetylglucosamine diphosphorylase (EC number|2.7.7.23) is an enzyme that catalyzes the chemical reaction:UTP + N acetyl alpha D glucosamine 1 phosphate ightleftharpoons diphosphate + UDP N acetyl D glucosamineThus, the two …   Wikipedia

  • UDP-N-acetylglucosamine 2-epimerase — In enzymology, an UDP N acetylglucosamine 2 epimerase (EC number|5.1.3.14) is an enzyme that catalyzes the chemical reaction:UDP N acetyl D glucosamine ightleftharpoons UDP N acetyl D mannosamineHence, this enzyme has one substrate, UDP N acetyl… …   Wikipedia

  • UDP-N-acetylglucosamine 4-epimerase — In enzymology, an UDP N acetylglucosamine 4 epimerase (EC number|5.1.3.7) is an enzyme that catalyzes the chemical reaction:UDP N acetyl D glucosamine ightleftharpoons UDP N acetyl D galactosamineHence, this enzyme has one substrate, UDP N acetyl …   Wikipedia

  • UDP-N-acetylglucosamine 6-dehydrogenase — In enzymology, an UDP N acetylglucosamine 6 dehydrogenase (EC number|1.1.1.136) is an enzyme that catalyzes the chemical reaction:UDP N acetyl D glucosamine + 2 NAD+ + H2O ightleftharpoons UDP N acetyl 2 amino 2 deoxy D glucuronate + 2 NADH + 2… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”