UDP-N-acetylglucosamine diphosphorylase

In enzymology, an UDP-N-acetylglucosamine diphosphorylase (EC number|2.7.7.23) is an enzyme that catalyzes the chemical reaction

:UTP + N-acetyl-alpha-D-glucosamine 1-phosphate $ightleftharpoons$ diphosphate + UDP-N-acetyl-D-glucosamine

Thus, the two substrates of this enzyme are UTP and N-acetyl-alpha-D-glucosamine 1-phosphate, whereas its two products are diphosphate and UDP-N-acetyl-D-glucosamine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase. Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate, uridylyltransferase, UDP-GlcNAc pyrophosphorylase, GlmU uridylyltransferase, Acetylglucosamine 1-phosphate uridylyltransferase, UDP-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and acetylglucosamine 1-phosphate uridylyltransferase. This enzyme participates in aminosugars metabolism.

tructural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FWY, PDB link|1FXJ, PDB link|1G95, PDB link|1G97, PDB link|1HM0, PDB link|1HM8, PDB link|1HM9, PDB link|1HV9, PDB link|1JVD, PDB link|1JVG, PDB link|1VM8, PDB link|2NPO, PDB link|2OI5, PDB link|2OI6, PDB link|2OI7, PDB link|2YQC, PDB link|2YQH, PDB link|2YQJ, and PDB link|2YQS.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-06-7."

Gene Ontology (GO) codes