UDP-N-acetylglucosamine 1-carboxyvinyltransferase

In enzymology, an UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC number|2.5.1.7) is an enzyme that catalyzes the chemical reaction

:phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine $ightleftharpoons$ phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine

Thus, the two substrates of this enzyme are phosphoenolpyruvate and UDP-N-acetyl-D-glucosamine, whereas its two products are phosphate and UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase. [Other names in common use include MurA transferase, UDP-N-acetylglucosamine 1-carboxyvinyl-transferase, UDP-N-acetylglucosamine enoylpyruvyltransferase, enoylpyruvate transferase, phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase, phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase, phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase, phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase, phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase, pyruvate-UDP-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetyl-glucosamine transferase, and pyruvic-uridine diphospho-N-acetylglucosaminyltransferase.] This enzyme participates in amino sugars metabolism and glycan biosynthesis.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A2N, PDB link|1DLG, PDB link|1EJC, PDB link|1EJD, PDB link|1EYN, PDB link|1NAW, PDB link|1Q3G, PDB link|1RYW, PDB link|1UAE, and PDB link|1YBG.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-27-2."

Gene Ontology (GO) codes